Dimethyl Sulfoxide
Apexbio Technology LLC Epinephrine HCl 55-31-2 10mM (in 1mL DMSO)
Epinephrine hydrochloride is an adrenergic receptor agonist functioning as both a hormone and neurotransmitter Structurally epinephrine hydrochloride is the hydrochloride salt form of epinephrine facilitating receptor binding and signal transduction mediated by adrenergic receptor subtypes ( and ) Upon receptor activation it initiates downstream signaling pathways through G-protein-coupled mechanisms influencing intracellular second messengers such as cAMP calcium influx and protein kinase activity In biomedical research epinephrine hydrochloride serves as a pharmacological tool for investigating adrenergic receptor-mediated physiological responses including cardiac function modulation bronchodilation metabolic processes and vasoconstriction Its controlled application aids in studying sympathetic nervous system mechanisms cellular signaling cascades cardiovascular pharmacology and stress response frameworks
Apexbio Technology LLC Salubrinal 405060-95-9 10mM (in 1mL DMSO)
Salubrinal is a cell-permeable inhibitor of eukaryotic translation initiation factor 2 alpha (eIF2 ) dephosphorylation exhibiting an IC50 of approximately 15 M It prevents phosphatase complexes from removing phosphate groups from eIF2 thus maintaining its phosphorylated state and modulating protein synthesis during cellular stress responses Salubrinal is utilized experimentally in vitro to investigate apoptotic mechanisms related to endoplasmic reticulum (ER) stress For instance it provides cytoprotection against ER stress-induced apoptosis triggered by protein glycosylation inhibitors or ER-Golgi trafficking inhibitors In vivo murine models employ salubrinal to explore cellular processes underlying oxidative stress and nephrotoxicity induced by chemotherapeutic treatments through modulation of ER stress-associated apoptosis signaling pathways Currently no clinical trials involving salubrinal have been reported
Cayman Chemical L-MethIonIn SulfoxIde 1g
A sulfoxide-modified methionine; increases weight gain in weanling mice in the diet at 6.3, 12.6, and 18.9 mmol/g; levels are decreased in patients with vitiligo
Apexbio Technology LLC Erlotinib Hydrochloride 183319-69-9 10mM (in 1mL DMSO)
Erlotinib hydrochloride (CAS 183319-69-9) is a small molecule inhibitor targeting the epidermal growth factor receptor (EGFR/HER-1) specifically blocking its tyrosine kinase activity By competitively inhibiting EGFR phosphorylation (IC50 2 nM) Erlotinib hydrochloride disrupts downstream signaling pathways involved in tumor cell proliferation apoptosis resistance migration and angiogenesis In vitro studies indicate this inhibitor induces G0/G1 cell cycle arrest and promotes apoptosis in cancer cell lines such as pancreatic (Bxpc-3 PANC-1) and hepatocellular carcinoma cells Erlotinib hydrochloride is widely studied in oncology research particularly in non-small cell lung cancer (NSCLC) and pancreatic cancer models
Apexbio Technology LLC Cinobufagin 470-37-1 10mM (in 1mL DMSO)
Cinobufagin (CAS 470-37-1) is a steroidal cardiac glycoside recognized for its inhibitory effect on the Na /K -ATPase pump Its inhibitory potency is approximately comparable to that of ouabain By impeding Na /K -ATPase activity cinobufagin disrupts ionic gradients altering intracellular calcium homeostasis and influencing cardiac and cellular functions In biomedical research cinobufagin serves as a valuable pharmacological tool to investigate ion transport mechanisms and explore related signaling pathways implicated in cellular physiology and pathology
Apexbio Technology LLC CO-1686 (AVL-301) 1374640-70-6 10mM (in 1mL DMSO)
CO-1686 (AVL-301 CAS 1374640-70-6) is an orally delivered irreversible small molecule inhibitor targeting mutated epidermal growth factor receptor (EGFR) It functions by forming a covalent bond at cysteine 797 in the ATP-binding domain of EGFR selectively inhibiting mutant variants such as L858R/T790M with reported IC50 values below 0 51 nM CO-1686 preferentially targets mutant EGFR over wild-type demonstrating approximately 22-fold selectivity Preclinical studies using non-small cell lung cancer (NSCLC) cell lines and xenograft models carrying EGFR mutations showed potent anti-proliferative and tumor regression effects Thus CO-1686 represents a valuable research tool in studying mutant EGFR-mediated oncogenesis
Apexbio Technology LLC Proparacaine HCl 5875-06-9 10mM (in 1mL DMSO)
Proparacaine HCl (CAS 5875-06-9) is a small-molecule antagonist of voltage-gated sodium channels By inhibiting sodium ion entry through these channels Proparacaine HCl effectively suppresses action potential generation and neuronal signaling Assays demonstrate an ED50 value of approximately 3 4 mM Due to its sodium channel inhibition Proparacaine HCl is utilized in scientific research to study neuronal excitability ion channel function and related electrophysiological processes
Apexbio Technology LLC Ifosfamide 3778-73-2 10mM (in 1mL DMSO)
Ifosfamide (CAS 3778-73-2) is an oxazaphosphorine-type alkylating agent structurally analogous to cyclophosphamide As a prodrug it undergoes hepatic activation via cytochrome P450-mediated hydroxylation generating reactive metabolites that form crosslinks within the DNA double strands This alkylation induces DNA damage subsequently inhibiting cell proliferation and promoting apoptosis in rapidly dividing cells Due to these cytostatic and cytotoxic properties Ifosfamide is widely evaluated in oncology research contexts particularly for various hematological malignancies and solid tumors
Apexbio Technology LLC GLPG0634 1206161-97-8 10mM (in 1mL DMSO)
GLPG0634 (CAS 1206161-97-8) is a selective small-molecule inhibitor targeting Janus kinase 1 (JAK1) It exhibits potent inhibitory activity against JAK1 and moderate inhibition against JAK2 with reported IC50 values of approximately 10 nM and 28 nM respectively GLPG0634 preferentially interferes with signal transduction pathways mediated by JAK1 affecting cytokine-induced phosphorylation of STAT1 and STAT5 thus attenuating differentiation of Th1 Th2 and to a lesser degree Th17 cells In preclinical rat models of collagen-induced arthritis oral administration reduced inflammatory cell infiltration and bone damage supporting its potential application in inflammatory disease research
Apexbio Technology LLC Rocilinostat (ACY-1215) 1316214-52-4 10mM (in 1mL DMSO)
Rocilinostat (ACY-1215 CAS 1316214-52-4) is a selective inhibitor of histone deacetylase 6 (HDAC6) HDAC6 enzymatically regulates various cellular processes including protein trafficking cell-cycle progression and cytoskeletal organization and its dysregulated activity is implicated in tumor progression and cancer metastasis Rocilinostat potently inhibits HDAC6 (IC50 5 nM) while showing minimal activity against other HDAC isoforms and sirtuins (IC50 1 M) Preclinical studies using multiple myeloma (MM) cell lines and xenograft mouse models demonstrated rocilinostat can enhance acetylation of -tubulin disrupt protein stability pathways and sensitize cancer cells to proteasome inhibitors such as bortezomib and carfilzomib resulting in increased apoptosis and reduction in tumor growth
Apexbio Technology LLC Tivozanib (AV-951) 475108-18-0 10mM (in 1mL DMSO)
Tivozanib (AV-951 CAS 475108-18-0) is a quinoline-urea derivative functioning as a potent inhibitor of vascular endothelial growth factor receptors (VEGFR) It primarily targets VEGFR-2 kinase demonstrating significant inhibitory activity in picomolar ranges (IC50 of approximately 160 pM) Additionally Tivozanib displays considerable selectivity causing minimal off-target interaction with c-kit In cellular assays it inhibits PDGFR and c-kit phosphorylation at nanomolar levels Preclinical evaluations revealed antitumor activity across multiple solid tumor xenograft models particularly renal cell carcinoma (RCC) Its mechanism and selectivity profile render it valuable for cancer research clinical investigation and preclinical efficacy assessments
Apexbio Technology LLC DMXAA (Vadimezan) 117570-53-3 10mM (in 1mL DMSO)
DMXAA (Vadimezan AS-1404) is a tumor vascular disrupting and apoptosis-inducing agent functioning primarily through inhibition of DT-diaphorase (DTD) It acts by suppressing DTD enzymatic activity showing an IC50 of approximately 62 5 M Additionally DMXAA inhibits various kinases notably VEGFR2 disrupting endothelial cells and blood vessel formation to induce tumor cell apoptosis and vascular necrosis Experimentally DMXAA demonstrates activity in murine tumor models including induction of apoptosis in endothelial cells and tumor vasculature promoting necrosis and tumor regression Therefore DMXAA is commonly used in oncology research focused on anti-angiogenesis and tumor vascular disruption mechanisms
Medchemexpress LLC XMU-MP-9 ,10 mM 1 mL in DMSO Solution
XMU-MP-9 is a bifunctional compound that binds to the C2 domain of Nedd4-1 and the allosteric site of K-Ras. XMU-MP-9 enhances the interaction between Nedd4-1 and K-Ras, induces conformational changes in the Nedd4-1/K-Ras complex, promotes the ubiquitination and degradation of multiple K-Ras mutants, and inhibits the proliferation of cells carrying K-Ras mutants. XMU-MP-9 can be used in cancer research.