Dimethyl Sulfoxide
Medchemexpress LLC Jsh-23 10Mm 1Ml Dmso Solution | HY-13982-10MM 1ML DMSO
Jsh-23 10Mm 1Ml Dmso Solution
Medchemexpress LLC Phenol, 2,2'-sulfinylbis[4,6-dichloro- | 844-26-8 | 99.0% | 372.05 | 1 ML
Bithionol sulfoxide is an anti-infection agent for parasites, possessing mutagenic activity. It can be used in the research of parasite infections such as paragonimiasis, flukes, and cestodes infection.
- Acts as an anti-infection agent for parasites.
- Exhibits mutagenic activity.
- Used in research of paragonimiasis, flukes, and cestodes infection.
- Shows toxicity to Neoparamoeba spp parasites in seawater.
- Effective against natural rumen fluke infections in dairy cattle.
Apexbio Technology LLC Flucytosine 2022-85-7 10mM (in 1mL DMSO)
Flucytosine also known as 5-Fluorocytosine (5-FC) is a fluorinated pyrimidine analogue with antifungal properties It exerts its biological activity by penetrating fungal cells and undergoing intracellular conversion into 5-fluorouracil (5-FU) via cytosine deaminase Subsequently 5-FU metabolites inhibit nucleic acid synthesis interfering with fungal RNA and DNA synthesis pathways thus blocking cellular proliferation In laboratory experiments Flucytosine is commonly utilized for antifungal susceptibility assays fungal growth inhibition studies as well as research into antifungal resistance mechanisms The typical reported in vitro antifungal activity displays IC50 values ranging from approximately 0 12 to 8 g/mL depending on fungal species and experimental conditions
Apexbio Technology LLC Idarubicin HCl 57852-57-0 10mM (in 1mL DMSO)
Idarubicin hydrochloride an anthracycline derivative structurally related to daunorubicin acts primarily by inhibiting DNA topoisomerase II It exerts cytotoxic effects through stabilization of DNA-topoisomerase II intercalation complexes inducing DNA strand breaks and apoptosis Idarubicin can be enzymatically activated intracellularly via NADPH-cytochrome C reductase enhancing DNA damage Experimentally it is commonly utilized in leukemia research particularly acute myeloid leukemia (AML) assessing cellular response to DNA damage apoptosis induction and mechanisms underlying drug resistance Idarubicin exhibits IC50 values typically ranging from low nanomolar to micromolar concentrations depending on cell line and assay conditions
Apexbio Technology LLC Nutlin-3a chiral 675576-98-4 10mM (in 1mL DMSO)
Nutlin-3a chiral (CAS 675576-98-4) is a small-molecule antagonist targeting mouse double minute 2 (MDM2) which functions as a negative regulator of the tumor suppressor TP53 By binding directly to the TP53-interacting pocket of MDM2 Nutlin-3a blocks the degradation of TP53 stabilizing the protein and activating TP53-dependent pathways Studies in solid tumors and lymphomas indicate that Nutlin-3a induces cell cycle arrest growth inhibition and apoptosis Research has demonstrated antitumor activity in vitro and in vivo highlighting its utility in studying TP53-related cell signaling pathways and its potential in cancer research applications
Apexbio Technology LLC Z-IETD-FMK 210344-98-2 10mM (in 1mL DMSO)
Z-IETD-FMK (CAS 210344-98-2) is a cell-permeable peptide-derived inhibitor targeting caspase-8 It reduces T-cell proliferation induced by stimuli such as phytohemagglutinin (PHA) or anti-CD3/anti-CD28 antibodies primarily through downregulation of CD25 expression without affecting IL-2 or IFN- secretion Additionally Z-IETD-FMK inhibits NF- B activation at higher concentrations (100 M) Studies also demonstrate its protective effects against TRAIL-induced apoptosis by inhibiting processing of procaspases-2 -3 -9 and PARP cleavage in cancer cell lines such as HCT116 and SW480
Apexbio Technology LLC AZD1208 1204144-28-4 10mM (in 1mL DMSO)
AZD1208 (CAS 1204144-28-4) is a selective orally bioavailable pan-Pim kinase inhibitor targeting Pim-1 Pim-2 and Pim-3 kinases with IC50 values of 0 4 nM 5 nM and 1 9 nM respectively Pim kinases are implicated in proliferative and anti-apoptotic signaling downstream of cytokines and growth factors frequently overexpressed in leukemia and lymphoma In vitro AZD1208 inhibits growth induces cell cycle arrest apoptosis and reduces phosphorylation of the anti-apoptotic protein Bcl-2 in AML cell lines Preclinically this compound suppresses tumor growth in AML xenograft models supporting its current clinical evaluation in AML and solid tumor trials
Apexbio Technology LLC Q-VD-OPh 1135695-98-5 10mM (in 1mL DMSO)
Q-VD-OPh is a pan-caspase inhibitor targeting caspases including 1 3 8 and 9 with IC50 values ranging from approximately 25 to 400 nM By blocking multiple caspase-mediated apoptotic pathways including caspase-9/3 caspase-8/10 and caspase-12 pathways Q-VD-OPh prevents apoptotic cell death induced by agents such as actinomycin D In research contexts this inhibitor serves as a tool to investigate apoptosis mechanisms across diverse cell types and species including human mouse and rat It is also used to enhance cell viability upon thawing from cryopreservation under standard cryoprotectant conditions
Hampton Research 30% V/V DIMETHYL SULFOX 1ML
HR2-428-28/Additive Screen 28 (C04), 1.0 ml - 30% v/v Dimethyl sulfoxide. Please note items from this supplier are non-returnable.
Selleck Chemical LLC Trametinib DMSO solvate S4484-25mg
Trametinib DMSO solvate is a highly specific and potent MEK1/2 inhibitor with IC50 of 0 92 nM/1 8 nM in cell-free assay Trametinib activates autophagy and induces apoptosis
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide, 67-68-5, MFCD00002089, 100mL
Linear Formula (CH3)2SO, ≥99.9%, Molecular Weight 78.13, ACS reagent, Synonym: DMSO
Selleck Chemical LLC Trametinib DMSO solvate S4484-1g
Trametinib DMSO solvate is a highly specific and potent MEK1/2 inhibitor with IC50 of 0 92 nM/1 8 nM in cell-free assay Trametinib activates autophagy and induces apoptosis
Bioworld DMSO, 100 mL
DMSO, Dimethyl SulfoxideTechnical Specifications:Grade: Molecular biologyForeign activity: DNase and RNase, none detectedAppearance: LiquidBoiling Point : 189 °C(lit.)Density : 1.10 g/mL(lit.)Melting Point: 16-19 °C(lit.)HS Code:2930.90.70